Symbol
Name
ID

Ccm2
cerebral cavernous malformation 2
MGI:2384924

Phenotype annotations related to cardiovascular system

Darker colors indicate more annotations

Human Phenotypes	Cerebral hemorrhage	Cerebral cavernous malformation	Stroke	Telangiectasia
Disease(s) Associated with CCM2
cerebral cavernous malformation 2

Mouse Phenotypes

abnormal cardiovascular system morphology

abnormal artery development

abnormal dorsal aorta morphology

dilated dorsal aorta

abnormal pharyngeal arch artery morphology

abnormal first pharyngeal arch artery morphology

abnormal second pharyngeal arch artery morphology

abnormal third pharyngeal arch artery morphology

aorta stenosis

abnormal vascular endothelial cell morphology

abnormal brain vasculature morphology

abnormal retina vasculature morphology

abnormal pericyte morphology

abnormal placental labyrinth vasculature morphology

abnormal angiogenesis

abnormal developmental vascular remodeling

abnormal vascular branching morphogenesis

abnormal cardinal vein morphology

decreased angiogenesis

abnormal vascular endothelial cell development

abnormal vasculogenesis

abnormal vitelline vasculature morphology

absent vitelline blood vessels

abnormal vascular smooth muscle morphology

dilated vasculature

dilated aortic sac

thin myocardium

abnormal heart development

decreased cardiac jelly amount

abnormal atrioventricular cushion morphology

failure of heart looping

abnormal sinus venosus morphology

delayed heart development

increased heart atrium size

enlarged heart

thin ventricular wall

hemopericardium

pericardial edema

intracranial hemorrhage

cerebellum hemorrhage

intracerebral hemorrhage

skin hemorrhage

poor circulation

impaired blood-brain barrier function

Availability

Mouse Genotype

Ccm2^{Gt(RRG051)Byg}/Ccm2^{Gt(RRG051)Byg}

Ccm2^tm1.1Etl/Ccm2^tm1.1Etl

Ccm2^tm1.1Kwhi/Ccm2^tm1.1Kwhi

Ccm2^tm1Sbn/Ccm2^tm1Sbn

Ccm2^{Gt(RRG051)Byg}/Ccm2⁺

Ccm2^tm1Etl/Ccm2^tm1Etl
Tg(Tek-cre)1Ywa/0 (conditional)

Ccm2^tm1Etl/Ccm2^tm1Etl (conditional)

Ccm2^tm1Mlkn/Ccm2^tm1Mlkn
Tg(Cdh5-cre/ERT2)1Rha/0 (conditional)

Ccm2^tm1Mlkn/Ccm2^tm1Mlkn
Nfatc1^tm1.1(cre)Bz/Nfatc1⁺ (conditional)

Ccm2^tm2.1Sbn/Ccm2^tm2.1Sbn
Tg(Tek-cre)1Ywa/0 (conditional)

Ccm2^tm2.1Sbn/Ccm2^tm2.1Sbn
Tg(Mx1-cre)1Cgn/0 (conditional)

Ccm2^tm1.1Etl/Ccm2^tm1Etl
Tg(Cdh5-cre/ERT2)1Rha/0 (conditional)

Ccm2^tm1Kwhi/Ccm2^tm1.1Kwhi
Tg(Tek-cre)1Ywa/0 (conditional)

Ccm2^tm1Kwhi/Ccm2^tm1.1Kwhi
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/? (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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